PIERRE COLEMAN

Biochemist taking informatics work into the lab.

Postdoctoral research associate at King's College London.

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ReDisulphID - a bioinformatic tool that uses available structural data to predict the presence of novel redox-active disulphide bonds in mammalian proteins.

StrucSeq - A python package to fetch and process data between protein structures and sequences.

GROMACS bash workflow - A molecular dynamics simulation workflow for protein protein interactions and disulphides.

Scitable (under construction) - turn tables of results into a polished scientific web app.

Coleman, P., Laddach, A., Anderson, R., Yang, X., Kumar, R., Shah, A., Fraternali, F., & Burgoyne, J. R. (2026). ReDisulphID: A discovery platform for thiol redox sensors identifies a druggable site regulating p53 activation. Redox Biology, 94, 104196.

Su, J., Zhao, Y., Coleman, P., Yang, X., Holt, M., Raabe, J., Cuello, F., Shah, A., Shattock, M. J., Zhang, M., & Burgoyne, J. R. (2026). Targeting PKGIα Cys⁴² attenuates cardiac dysfunction in heart failure with preserved ejection fraction. Science Advances, 12(34), eaec8088.

Su, J., Coleman, P., Ntorla, A., Anderson, R., Shattock, M. J., & Burgoyne, J. R. (2023). Sensing cytosolic DNA lowers blood pressure by direct CGAMP-dependent PKGI activation. Circulation, 148(13), 1023–1034.

Cruz-Gallardo, I., Martino, L., Kelly, G., Atkinson, R. A., Trotta, R., De Tito, S., Coleman, P., Ahdash, Z., Gu, Y., Bui, T. T., & Conte, M. R. (2019). LARP4A recognizes Polya RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2W motif, revealing interplay between PABP, LARP4A and mRNA. Nucleic Acids Research, 47(8), 4272–4291.

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